Published in Scientific Bulletin. Series F. Biotechnologies, Vol. XXIX, Issue 2
Written by Marian TOADER, Nicoleta RADU, Narcisa Elena BĂBEANU, Radu-CristianTOMA, Viviana ROMAN
This study aimed to predict, through applying math models, the cytotoxic effects of marine algae-derived biomaterials. The tested bioproducts included both polysaccharide-rich and gold-functionalized extracts, and the cytotoxicity was evaluated in vitro on HepG2 and Caco-2 cell lines. The results obtained revealed that the bioproduct derived from Chlorella sp., enriched with gold, exhibited the highest cytotoxicity (100%), with an IC50=134.75 µL/mL. The bioproduct containing only polysaccharides showed significantly lower cytotoxicity. Predictions regarding the cytotoxicity of selected bioproducts on HepG2 cells highlighted the enhanced activity of gold-functionalized extracts compared to simple polysaccharides. Among all the tested samples, the polysaccharides derived from Undaria pinnatifida exhibited the strongest cytotoxic effect on the Caco-2 cell line, followed by the extract from Porphyra umbilicalis. In conclusion, the results obtained through mathematical prediction demonstrate the potential of marine-derived sources in developing new bioproducts with antitumor properties.
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{simplepopup popup="false" name="Citation12"}TOADER M., RADU N., BABEANU N.E., R.C., ROMAN V. 2025, EVALUATION OF THE CYTOTOXICITY OF SOME BIOMATERIALS DERIVED FROM ALGAL POLYSACCHARIDES USING MATH MODELS. Scientific Bulletin. Series F. Biotechnologies, Vol. XXIX, Issue 2, ISSN 2285-1364, 94-102. {/simplepopup}